What is DMSO? 

You are probably wondering what exactly DMSO is, its uses, effectiveness and possible side effects. Let’s dive right in, and get the “BIG” words out of the way. DMSO or Dimethyl Sulfoxide having a CAS Number of 67-68-5 is a highly polar aprotic solvent that has a number of interesting uses.

DMSO increases the absorption kinetics of many different compounds through the epidermis into the dermis. This characteristic of DMSO is taken advantage of for transdermal drug delivery.
The FDA has cleared DMSO for use in relieving interstitial cystitis.

DMSO rose to fame due to its ability to easily pass through the skin and other biological membranes. It’s a sulfur-based compound with claims of amazing healing properties. 

DMSO is a powerful free radical scavenger and an effective anti-inflammatory agent. It also has pain-relieving, collagen-softening, and anti-inflammatory characteristics, making it an incredibly effective natural pain reliever.

Herbal Skin Care

What health conditions can DMSO be used for?

Osteoarthritis, rheumatoid arthritis, joint inflammation, any chronic pain, bursitis, tendonitis, musculoskeletal pain, muscle cramps, leg cramps, migraine headaches, high blood pressure, high cholesterol, hangover, allergies, parasitic infections of the intestinal and urogenital tracts, scleroderma, scar tissue, stretch marks, sun/wind burn, cuts and abrasions, chronic constipation, sour stomach, ulcers, diverticulosis, premenstrual syndrome (PMS), mood elevation, poor circulation, type 2 diabetes, liver problems, lung disorders including emphysema and pneumonia, autoimmune disorders, chronic fatigue, fibromyalgia, and just about any other ailment you can name.

The Power of DMSO

DMSO works in several ways. First, as a topical compound, it has analgesic properties and reduces pain quickly—which is why it is great for rubbing on sore muscles and joints. Laboratory studies suggest that it decreases pain by blocking peripheral nerve C fibers. DMSO reduces inflammation by acting as an antioxidant—and so it neutralizes some of the free radicals that promote inflammation. Some evidence suggests that it also can ease swelling, further helping with aches and pains.

Herbal Skin Care
Herbal Skin Care

DMSO for Arthritis & Back Pain

DMSO, also known as dimethyl sulfoxide, is a powerful solvent that is also able to penetrate through all tissues except for nails, hair and tooth enamel. Some believe that dimethyl sulfoxide can be used to help treat arthritis, due to this chemical's ability to work as an antioxidant, the Dimethyl Sulfoxide Information Center explains. DMSO can potentially help reduce inflammation and cellular damage and be used to relieve the symptoms of arthritis. 


How to Apply DMSO Topically


Clean your hands and the application area. It is important to wash your hands and under your nails thoroughly before using topical DMSO. Also clean the area you are applying DMSO to. To apply to skin, you can use your fingers, cotton balls, a spritz nozzle or a roll-on applicator. `Wash your hands after applying . 


Temporary skin irritation is normal with DMSO, so before the first use, apply it to a small area on your forearm to test your skin sensitivity so you know what to expect. To reduce skin irritation, allow the DMSO to be absorbed for a few minutes and then wipe off any excess. If irritation persists, rinse with cool water.


When using dimethyl sulfoxide for pain relief, apply it to an area larger than where the pain is. A few additional inches each way should suffice. With DMSO, a little goes a long way! Start small and apply more as you feel is needed. You will be the best judge of how much and how often to apply it. 

Jack Arnest

Amazon Customer

"It is very effective for chronic low back pain.  Applied some to my wife's lower back which hurts her every day, and after about 30 minutes, she reported that the pain was gone and fell asleep on the couch. That was around noon.  Asked her in the evening how she felt and she said she still had no pain. I was amazed because she has to take very powerful pain medication around the clock and that only reduces her pain somewhat. This completely rid her of pain. Amazing."

Cathy Koziol

Amazon Custoner

"I had a very hard fall and spent weeks in pain. Then I read a book that recommended DMSO and a few medical doctors who supported the product as a treatment for injuries and joint pain. When I applied the product generously to the most serious injuries in my hip region, I could actually feel the penetration and that it was making an impact. You must apply generously for this to happen. DMSO contributed significantly to speeding my recovery. I highly recommend it."

Rosiland Dupont

Amazon Customer

I am so glad to have this. It has made a big difference to my pain levels. And then thanks to the book I got which discusses DMSO in great detail, I am having a greater impact on my comfort level than ever before. But it is not good for just pain, it covers many other ailments as well. I feel like shouting to the rooftops about the wonderful products this is! I've been battling pain for close to 10 years and this is definitely the best way to cope with it, and it has restorative properties as well as anti-inflammatory ones. I cannot recommend this product enough!


Amazon Customer

"My right shoulder has been bothering me ever since I separated it almost 30 years ago, in my job as a firefighter. I've been taking Ibuprofen, and getting cortisone shots, to no avail. Then I remembered something that my Aunt used to use on her race horses, 45 years ago, DSMO. I went to a local feed store, and got a bottle of DSMO, recommended for horses, and started applying it. To my surprise, it actually helped diminish the pain, but was kind of messy to use. I got on the web, and discovered the roll on bottles , sold by the DSMO Store."

Inflamed tissues fill with water. This creates pain from the additional pressure which leads to more inflammation and additional injury. DMSO draws water out of inflamed tissues and reduces swelling very quickly. DMSO also acts as an antioxidant which helps it prevent free radical damage in injured tissues. Many people with arthritis also get great relief from DMSO.

People have been known to use DMSO to help with these conditions:

  • Inflammatory diseases
  • Joint pain relief
  • Gastrointestinal disorders
  • Psoriasis
  • Eczema
  • Shingles
  • Candida
  • Tendonitis
  • Interstitial Cystitis
  • Autoimmune Disorders
  • Ulcerative Colitis
  • Varicose  veins
  • Burns and scar tissue
  • Musculoskeletal  disorders
  • Regional Pain Syndrome
  • Hemorrhoids
  • Muscle spasms
  • Respiratory Distress Syndrome
  • Bursitis
  • General stiffness and soreness
  • To improve range of motion

Fast Relief From Pain & Inflammation